2024 Targeting wee1 kinase in cancer

Targeting wee1 kinase in cancer

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WebJun 25, 2024 · In our research, we found that WEE1 inhibitor (AZD1775) as single agent showed anti-tumor effects in PC cells, however, targeting WEE1 upregulated p-ATM level. Here, we observed that co-targeting of WEE1 and ATM acted synergistically to reduce cell proliferation and migration, and to induce DNA damage in vitro. WebNov 15, 2024 · WEE1 has emerged as an attractive target in epithelial ovarian cancer (EOC), but how EOC cells may alter their sensitivity to WEE1 inhibition remains unclear.

Targeting WEE1 Inhibits Growth of Breast Cancer Cells That Are ...

WebNov 1, 2024 · Abstract. In the past decade, Wee1 inhibition has received widespread attention as a cancer therapy. Our research aims to discover effective, selective and drug-like Wee1 inhibitors. Herein, a series of compounds with pyrrolo [2,3-d]pyrimidine-based heterocycles were designed, synthesized and confirmed to inhibit Wee1 kinase. WebJul 1, 2011 · WEE1 kinase is a key molecule in maintaining G₂-cell-cycle checkpoint arrest for premitotic DNA repair. Whereas normal cells repair damaged DNA during G₁-arrest, cancer cells often have a deficient G₁-arrest and largely depend on G₂-arrest. The molecular switch for the G₂-M transition is held by WEE1 and is pushed forward by CDC25. my first adventure finding the dragon

Targeting WEE1 Kinase in Cancer Request PDF - ResearchGate

WebDec 7, 2024 · Selinexor for use in children with cancer is also being explored with other novel therapies, including small molecules targeting CDK 4/6 (palbociclib) and Wee1 … WebJul 1, 2016 · WEE1 kinase plays a crucial role in the G2-M cell-cycle checkpoint arrest for DNA repair before mitotic entry. Normal cells repair damaged DNA during G1 arrest; … WebAug 15, 2024 · Abstract. Wee1 is a protein kinase that regulates the G 2 checkpoint and prevents entry into mitosis in response to DNA damage. Cyclin-dependent kinases (CDK) … off white belt nearby

WEE1 Kinase Targeting Combined with DNA-Damaging Cancer …

Frontiers Targeting the DNA Damage Response for Cancer …

WebTargeting the checkpoint kinase WEE1. Selective sensitization of cancer cells to DNA-damaging drugs. Paola Indovina. 1,2. ... Tse AN, Carvajal R, Schwartz GK. Targeting check-point kinase 1 in cancer therapeutics. Clin Cancer Res 2007; 13:1955-60. 11. Kawabe T. G. 2. checkpoint abrogators as anticancer drugs. Mol Cancer Ther 2004; 3:513-9. WebFeb 3, 2024 · WEE1 is an attractive therapeutic target because cancer cells treated with cytotoxic chemotherapy rely on the G 2 –M checkpoint for repair, particularly if the G 1 checkpoint is defective as in TP53-mutant cancers. off white belt neckWebJan 1, 2024 · Targeting WEE1 as a cancer therapy. Recent studies have shown that WEE1 inhibition can overcome chemotherapy resistance in the treatment of cancer cells [130], [131]. This is because many types of chemotherapy are based on producing DNA damage in cancer cells, but if WEE1 protein kinase is activated it will prevent the death of cells with … off white belt model

"WebSep 21, 2024 · Among them, the most promising ones target the WEE1 kinase family, which has a crucial role in cell cycle regulation and DNA damage identification and repair in both … " - Targeting wee1 kinase in cancer

Targeting wee1 kinase in cancer

Cell cycle involvement in cancer therapy; WEE1 kinase, a potential ...

WebOct 1, 2016 · There are few WEE1 inhibitors and there is scope to improve WEE1 inhibitor selectivity and the properties of the inhibitors to permit targeting of specific cancer types. … WebMar 1, 2024 · (b) Reactivation of the HR pathway in tumors with acquired resistance to PARP inhibitors might be counteracted by various tyrosine kinase inhibitors (such as VEGF-targeted therapies) or agents targeting epigenetic regulators of HR-related genes (such as BET domain inhibitors). (c) Cancer cells depend on replication stress response for survival.

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WebSep 21, 2024 · The WEE1 kinase family consists of three serine/threonine kinases sharing conserved molecular structures and encoded by the following genes: WEE1 (WEE1 G2 … WebOct 28, 2024 · Wee1 expression and effect of AZD1775 with IR in cervical cancer cells. Cervical cancer cell lines showed lower intensities of Wee1 expression as opposed to …

WebNov 26, 2024 · WEE1, the founding member of the WEE kinase family, has been implicated in over a dozen cancer types. This has led to extensive efforts to develop inhibitors; for … WebJul 9, 2024 · WEE1 is a protein kinase involved in many cellular processes, one of which is its role as a regulator of the S-phase and G2-M cell-cycle checkpoint, which respond to DNA damage or replication stress. The majority of human cancer cells have a deficient G1-S checkpoint, often via mutation of p53, and are particularly reliant on a functional G2-M ...

WebSep 15, 2024 · Actually, WEE1, a mitotic inhibitor kinase, participates in the regulation of the DNA damage repair pathway, and its therapeutic inhibition along with chemotherapy is currently under clinical trials investigation for cancer treatment [58,59,60,61,62,63,64,65]. Furthermore, Lal et al. demonstrated the role of WEE1 as a HuR target, both in vitro ... WebFeb 19, 2024 · The human genome encodes 538 protein kinases that transfer a γ-phosphate group from ATP to serine, threonine, or tyrosine residues. Many of these kinases are …

WebMar 15, 2024 · Furthermore, protein or activity levels of AURKB and WEE1 decreased in melanoma cells when pharmacological agents targeting upstream (V600E)B-RAF or mitogen-activated protein kinase were used to ...

WebJun 1, 2024 · Targeting the cell cycle checkpoints and DNA damage response are promising therapeutic strategies for cancer. Adavosertib is a potent inhibitor of WEE1 kinase, which plays a critical role in regulating cell cycle checkpoints. However, the effect of adavosertib on hepatocellular carcinoma (HCC) treatment, including sorafenib-resistant HCC, has not … off white belt packagingWebJul 1, 2024 · Thus, targeting WEE1 is a promising anti-cancer therapeutic strategy in standard therapy resistant ER+ breast cancer. Despite the success of antiestrogens in extending overall survival of patients with estrogen receptor positive (ER+) breast tumors, resistance to these therapies is prevalent. ... Do K, Doroshow JH, Kummar S. Wee1 Kinase … off white belt on saleWebJul 5, 2011 · WEE1 kinase, as gatekeeper of the G 2-checkpoint arrest, holds potential as a therapeutic target to manipulate entry into mitosis of cancer cells. Compelling preclinical … off white belt pngWebFeb 3, 2024 · Cotreatment of PARGi and Wee1i shows synergistic cancer cell killing in vitro To assess possible synergies between targeting PARG and DDR candidates (ATR, CHK1, and Wee1), we performed a focused drug screen in the established PDAC cell line, PANC1. ATRi and CHK1i were not synergistic with PARGi (Supplementary Fig. S1A). off white belt nzWebApr 3, 2014 · Abstract. Wee1 is a major regulator of mitotic entry. It phosphorylates and inactivates CDC2/ CDK1, and its functional role is considered to be in G2 checkpoint signaling. MK-1775, a potent and selective small molecular inhibitor of Wee1 kinase, has been recently shown to have activity sensitizing to DNA-damaging agents and … off white belt on peopleWebFeb 17, 2024 · As most cancer therapies aim to induce lethal amounts of DNA damage in cancer cells, Wee1 overexpression promotes cancer cell survival (and resistance) by … off white belt wearingWebJan 12, 2024 · The cell-cycle checkpoint kinase WEE1 is emerging as a therapeutic target for cancer treatment. However, how its catalytic activity is regulated remains poorly understood, and reliable biomarkers ... off white belt reps