WebWe found that overexpression of TLR7 in transgenic mice (TLR7.1Tg) leads to marked alterations of transitional (T1) B cells, associated with their expansion and proliferation … WebNov 24, 2024 · Overexpression of TLR7 or topical treatment with TLR7 ligand amplifies disease in several lupus models [5,6,7,8,9], and TLR7 is required in B cells for its pathogenic effect [10,11,12]. Increased expression of the X-linked TLR7 gene in female B cells due to impaired X-chromosome inactivation may also contribute to the sex bias in SLE [13•, 14].
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WebApr 9, 2024 · There is also conflicting evidence as to how TLR7 overexpression causes autoimmunity, particularly, the relative roles of TLR7-driven spontaneous germinal centres (GCs) versus the role of TLR7-driven double-negative B cells; the latter have been proposed to originate extrafollicularly and be pathogenic in lupus1. Effector or memory … WebNov 18, 2013 · We found that overexpression of TLR7 in transgenic mice (TLR7.1Tg) leads to marked alterations of transitional (T1) B cells, associated with their expansion and proliferation within the splenic red pulp (RP). This phenotype was intrinsic to the T1 subset of B cells and occurred independently of type 1 IFN signals. goldenchopstickswestland
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WebJul 28, 2024 · We found that TLR7 overexpression led to the reduction of B10 cells whereas TLR7 deficiency enhanced B10 cell frequency. TLR7 expression in B cells was inversely correlated with their IL-10 production capacity and IL-10 mediated inhibition of IFNγ production by CD4 + T cells. WebJun 27, 2006 · The y-linked autoimmune accelerating (yaa) locus is a potent autoimmune disease allele.Transcription profiling of yaa-bearing B cells revealed the overexpression of a cluster of X-linked genes that included Tlr7.FISH analysis demonstrated the translocation of this segment onto the yaa chromosome. The resulting overexpression of Tlr7 increased … WebApr 4, 2024 · TLR7 Expression Aggravates Invasive Pulmonary Aspergillosis by Suppressing Anti-Aspergillus Immunity of Macrophages. Differential TLR7-mediated cytokine expression by R848 in M-CSF- versus GM-CSF-derived macrophages after LCMV infection. TLR7 Is Critical for Anti-Viral Humoral Immunity to EV71 Infection in the Spinal Cord. golden chopsticks westland menu